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Polydioxanone is used for biomedical applications because it is fully absorbed by hydrolysis within 4 to 6 months and does not create any scar tissue. The foreign body stimulates collagen synthesis and the skin structure created will hold for approximately 12 months.

Short smooth threads can be inserted into the dermis to stimulate production of structural skin proteins like collagen, elastin, and fibrin resulting in a smoothing and subtle plumping effect.

Barbed threads can be used for a mild lifting and collagen stimulating effect, especially in patients who are not candidates for a surgical facelift.